Publications

 

Per year, contribution of the Proteomics Center indicated by ‘#’

» Mandemaker IK, Geijer ME, Kik I, Bezstarosti K#, Rijkers E#, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA#, Vermeulen W, Marteijn JA (2018) DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones. EMBO Rep pii: e45566. doi: 10.15252/embr.201745566.

» Van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW#, Que I, Kaijzel EL, Te Riet L, MacFarlane E, Das D, van der Linden R, Vermeij M, Demmers JA#, Mastroberardino PG, Davis EC, Yanagisawa H, Dietz H, Kanaar R, Essers J (2018) Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation. Cardiovasc Res doi: 10.1093/cvr/cvy150.

» Baroncelli M, van der Eerden BCJ, Chatterji S, Rull Trinidad E, Kan YY, Koedam M, van Hengel IAJ, Alves RDAM, Fratila-Apachitei LE, Demmers JAA#, van de Peppel J, van Leeuwen JPTM (2018) Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive. Tissue Eng Part A doi: 10.1089/ten.TEA.2017.0448.

» Schilders K, Eenjes E, Edel G, de Munck AB, van Kempen MB, Demmers J#, Wijnen R, Tibboel D, Rottier RJ (2018) Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res 27(1):75-85.

» Estruch SB, Graham SA, Quevedo M, Vino A, Dekkers DHW#, Deriziotis P, Sollis E, Demmers J#, Poot RA, Fisher SE (2018) Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disordersHum Mol Genet 27(7):1212-1227.

» Ding D, Bergmaier P, Sachs P, Klangwart M, Rückert T, Bartels N, Demmers J#, Dekker M, Poot RA, Mermoud JE (2018) The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genesJ Biol Chem 293(8):2711-2724.

» van der Wal L#, Bezstarosti K#, Sap KA#, Dekkers DHW#, Rijkers E#, Mientjes E, Elgersma Y, Demmers JAA# (2018) Improvement of ubiquitylation site detection by Orbitrap mass spectrometryJ Proteomics 172:49-56.

» Baroncelli M, van der Eerden BC, Kan YY, Alves RD, Demmers JA#, van de Peppel J, van Leeuwen JP (2017) Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralizationJ Cell Physiol 233(1):387-395.

» Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K#, Hoeijmakers JH, Demmers JA#, Vermeulen W, Marteijn JA. DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathwaySci Rep 7(1):15353. doi: 10.1038/s41598-017-15194-y.

» Sap KA#, Bezstarosti K#, Dekkers DH#, Voets O, Demmers JA# (2017) Quantitative proteomics reveals extensive changes in the ubiquitinome after perturbation of the proteasome by targeted dsRNA mediated subunit knockdown in DrosophilaJ Proteome Res, doi:10.1021/acs.jproteome.7b00156.

» Adone Mohd-Sarip, Miriam Teeuwssen, Alice G. Bot, Maria J. De Herdt, Stefan M. Willems, Robert J. Baatenburg de Jong, Leendert H. J. Looijenga, Diana Zatreanu, Karel Bezstarosti#, Job van Riet Edwin Oole, Wilfred F.J. van Ijcken, Harmen J. G. van de Werken, Jeroen A.A. Demmers#, Riccardo Fodde, and C. Peter Verrijzer (2017) DOC1-dependent recruitment of NURD reveals antagonism with SWI/SNF during epithelial-mesenchymal transition in oral cancer cells. Cell Reports 20(1):61-75.

» Brum, A. M., van der Leije, C. S., Schreuders-Koedam, M., Verhoeven, J., Janssen, M., Dekkers, D. H.#, Demmers, J. A.#, Eijken, M., van de Peppel, J., van Leeuwen, J. P. and van der Eerden, B. C. (2017) Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation. JBMR PLUS. doi:10.1002/jbm4.10003

» Moen MJ, Adams HH, Brandsma JH, Dekkers DH#, Akinci U, Karkampouna S, Quevedo M, Kockx CE, Ozgür Z, van IJcken WF, Demmers J#, Poot RA (2017) An interaction network of mental disorder proteins in neural stem cells. Transl Psychiatry 7(4):e1082. doi: 10.1038/tp.2017.52.

» Kuzniar A, Laffeber C, Eppink B, Bezstarosti K#, Dekkers D#, Woelders H, Zwamborn AP, Demmers J#, Lebbink JH, Kanaar R (2017) Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields. PLoS One 12(2):e0170762.

» van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urbán N, Dekkers DH#, Demmers JA#, Guillemot F (2017) Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron 93(2):348-361.

» Nanou A, Toumpeki C, Lavigne MD, Lazou V, Demmers J#, Paparountas T, Thanos D, Katsantoni E (2017) The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions. Nucleic Acids Res 45(1):142-154.

» Engelen-Lee J, Blokhuis AM, Spliet WG, Pasterkamp RJ, Aronica E, Demmers JA#,Broekhuizen R, Nardo G, Bovenschen N, Van Den Berg LH (2017) Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis. Amyotroph Lateral Scler Frontotemporal Degener 18(3-4):210-220.

» Papageorgiou DN, Karkoulia E, Amaral-Psarris A, Burda P, Kolodziej K, Demmers J#, Bungert J, Stopka T, Strouboulis J (2016) Distinct and overlapping DNMT1 interactions with multiple transcription factors in erythroid cells: Evidence for co-repressor functions. Biochim Biophys Acta 1859(12):1515-1526.

» Drost R, Dhillon KK, van der Gulden H, van der Heijden I, Brandsma I, Cruz C, Chondronasiou D, Castroviejo-Bermejo M, Boon U, Schut E, van der Burg E, Wientjens E, Pieterse M, Klijn C, Klarenbeek S, Loayza-Puch F, Elkon R, van Deemter L, Rottenberg S, van de Ven M, Dekkers DH#, Demmers JA#, van Gent DC, Agami R, Balmaña J, Serra V, Taniguchi T, Bouwman P, Jonkers J (2016) BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest 126(8):2903-18.

» Urbán N, van den Berg DL, Forget A, Andersen J, Demmers JA#, Hunt C, Ayrault O, Guillemot F (2016) Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science 353(6296):292-5.

» Yu N, Signorile L, Basu S, Ottema S, Lebbink JH, Leslie K, Smal I, Dekkers D#, Demmers J#, Galjart N (2016) Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells. Curr Biol 26(13):1728-36.

» Blokhuis AM, Koppers M, Groen EJ, van den Heuvel DM, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JA#, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ (2016) Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. Acta Neuropathol 132(2):175-96.

» Ray P, De S, Mitra A, Bezstarosti K#, Demmers JA#, Pfeifer K, Kassis JA (2016) Combgap contributes to recruitment of Polycomb group proteins in Drosophila. Proc Natl Acad Sci U S A 113(14):3826-31.

» Salih M, Demmers JA#, Bezstarosti K#, Leonhard WN, Losekoot M, van Kooten C, Gansevoort RT, Peters DJ, Zietse R, Hoorn EJ; DIPAK Consortium (2016) Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease. J Am Soc Nephrol 27(10):3079-3092.

» Wens SC, Schaaf GJ, Michels M, Kruijshaar ME, van Gestel TJ, In ‘t Groen S, Pijnenburg J, Dekkers DH#, Demmers JA#, Verdijk LB, Brusse E, van Schaik RH, van der Ploeg AT, van Doorn PA, Pijnappel WW (2016) Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe Disease. Circ Cardiovasc Genet 9(1):6-13.

» den Reijer PM, Haisma EM, Lemmens-den Toom NA, Willemse J, Koning RI, Demmers JA#, Dekkers DH#, Rijkers E#, El Ghalbzouri A, Nibbering PH, van Wamel W (2016) Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model. PLoS One 11(1):e0145722. Erratum in: PLoS One 11(3):e0152544. Koning, R A [corrected to Koning, R I].

» Lu X, Meima ME, Nelson JK, Sorrentino V, Loregger A, Scheij S, Dekkers DH#, Mulder MT, Demmers JA#, M-Dallinga-Thie G, Zelcer N, Danser AH (2016) Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism. Circ Res 118(2):222-9.

» Sap KA#, Bezstarosti K#, Dekkers DH#, van den Hout M, van Ijcken W, Rijkers E#, Demmers JAA# (2015) Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster. Proteomics 15(4):725-38.

» van Erp S, van den Heuvel DM, Fujita Y, Robinson RA, Hellemons AJ, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JA#, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Dev Cell 35(5):537-52.

» Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J#, Bezstarosti K#, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E (2015) Control of developmentally primed erythroid genes by combinatorial co-repressor actions.Nat Commun 6:8893.

» Doyen CM, Chalkley GE, Voets O, Bezstarosti K#, Demmers JA#, Moshkin YM, Verrijzer CP (2015) A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Cell Rep 13(7):1310-8.

» Voets E, Marsman J, Demmers J#, Beijersbergen R, Wolthuis R (2015) The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Sci Rep 5:14798.

» Brideau NJ, Coker H, Gendrel AV, Siebert CA, Bezstarosti K#, Demmers J#, Poot RA, Nesterova TB, Brockdorff N (2015) Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome. Mol Cell Biol 35(23):4053-68.

» Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA#, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA (2015) The core spliceosome as target and effector of non-canonical ATM signalling. Nature 523(7558):53-8.

» Twigt JM, Bezstarosti K#, Demmers J#, Lindemans J, Laven JS, Steegers-Theunissen RP (2015) Preconception folic acid use influences the follicle fluid proteome. Eur J Clin Invest 45(8):833-41.

» Engelen E, Brandsma JH, Moen MJ, Signorile L, Dekkers DH#, Demmers J#, Kockx CE, Ozgür Z, van IJcken WF, van den Berg DL, Poot RA (2015) Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry. Nat Commun 6:7155.

» Papadopoulos P, Gutiérrez L, Demmers J#, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L (2015) TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis. Mol Cell Biol 35(12):2103-18.

» Erdem-Eraslan L, Gao Y, Kloosterhof NK, Atlasi Y, Demmers J#, Sacchetti A, Kros JM, Sillevis Smitt P, Aerts J, French PJ (2015) Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation. Eur J Cancer 51(7):893-903.

» Raj VS, Lamers MM, Smits SL, Demmers JA#, Mou H, Bosch BJ, Haagmans BL (2015) Identification of protein receptors for coronaviruses by mass spectrometry. Methods Mol Biol 1282:165-82.

» Braakman RB, Bezstarosti K#, Sieuwerts AM, de Weerd V, van Galen AM, Stingl C, Luider TM, Timmermans MA, Smid M, Martens JW, Foekens JA, Demmers JA#, Umar A (2015) Integrative analysis of genomics and proteomics data on clinical breast cancer tissue specimens extracted with acid guanidinium thiocyanate-phenol-chloroform. J Proteome Res 14(3):1627-36.

» Morhayim J, van de Peppel J, Demmers JA#, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP (2015) Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. FASEB J 29(1):274-85.

» Meinders M, Kulu DI, van de Werken HJ, Hoogenboezem M, Janssen H, Brouwer RW, van Ijcken WF, Rijkers E#, Demmers JA#, Krüger I, van den Berg TK, Suske G, Gutiérrez L, Philipsen S (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation, and platelet formation and function. Blood 125(12):1957-67.

» Morhayim J, van de Peppel J, Demmers JA#, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP (2014) Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. FASEB J 29(1):274-85.

» Giraud G, Stadhouders R, Conidi A, Dekkers DH, Huylebroeck D, Demmers JA#, Soler E, Grosveld FG (2014) NLS-tagging: an alternative strategy to tag nuclear proteins. Nucleic Acids Res 42(21).

» Bohla D, Herold M, Panzer I, Buxa MK, Ali T, Demmers J#, Krüger M, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R (2014) A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS One 9(9):e107765.

» van Haren J, Boudeau J, Schmidt S, Basu S, Liu Z, Lammers D, Demmers J#, Benhari J, Grosveld F, Debant A, Galjart N (2014) Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension. Curr Biol 24(15):1778-85.

» Schmidt ER, Brignani S, Adolfs Y, Lemstra S, Demmers J#, Vidaki M, Donahoo AL, Lilleväli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ (2014)Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron 83(2):372-87.

» Reddy BA, van der Knaap JA, Bot AG, Mohd-Sarip A, Dekkers DH#, Timmermans MA, Martens JW, Demmers JA#, Verrijzer CP (2014) Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization. Mol Cell 53(3):458-70.

» Geiger JC, Lipka J, Segura I, Hoyer S, Schlager MA, Wulf PS, Weinges S, Demmers JA#, Hoogenraad CC, Acker-Palmer A (2014) The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development. Dev Cell 28(4): 381-93.

» van der Vaart B, van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, Demmers J#, Olieric N, Maly IV, Hoogenraad CC, Akhmanova A (2013) CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor. Dev Cell 27(2):145-60.

» Moshkin YM, Doyen CM, Kan TW, Chalkley GE, Sap K, Bezstarosti K#, Demmers JA#, Ozgur Z, van Ijcken WF, Verrijzer CP (2013) Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A.PLoS Genet 9(9):e1003719.

» Ruiz-Saenz A, van Haren J, Sayas L, Rangel L, Demmers J#, Millán J, Alonso MA, Galjart N, Correas I (2013) Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex. J Cell Sci 126(Pt 20):4589-601.

» Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J#, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M (2013)The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell 13(4):403-18.

» Pourfarzad F, Aghajanirefah A, de Boer E, Ten Have S, Bryn van Dijk T, Kheradmandkia S, Stadhouders R, Thongjuea S, Soler E, Gillemans N, von Lindern M, Demmers J#, Philipsen S, Grosveld F (2013) Locus-Specific Proteomics by TChP: Targeted Chromatin Purification. Cell Rep 4(3):589-600.

» Bergink S, Theil AF, Toussaint W, De Cuyper IM, Kulu DI, Clapes T, van der Linden R, Demmers JA#, Mul EP, van Alphen FP, Marteijn JA, van Gent T, Maas A, Robin C, Philipsen S, Vermeulen W, Mitchell JR, Gutiérrez L (2013) Erythropoietic Defect Associated with Reduced Cell Proliferation in Mice Lacking the 26S Proteasome Shuttling Factor Rad23b. Mol Cell Biol 33(19):3879-92.

» Gagliardi A, Mullin NP, Ying Tan Z, Colby D, Kousa AI, Halbritter F, Weiss JT, Felker A, Bezstarosti K#, Favaro R, Demmers J#, Nicolis SK, Tomlinson SR, Poot RA, Chambers I (2013) A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J 32(16):2231-47.

» Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JA#, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF, van der Laan LJ (2013) Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U S A 110(32):13109-13.

» Raj VS, Mou H, Smits SL, Dekkers DH#, Müller MA, Dijkman R, Muth D, Demmers JA#, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL (2013) Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495(7440):251-4.

» Schwertman P, Bezstarosti K, Laffeber C, Vermeulen W, Demmers JA#*, Marteijn JA* (2013) An immunoaffinity purification method for the proteomic analysis of ubiquitinated protein complexes. Anal Biochem 440(2):227-36.

» Cécile M. Doyen, Yuri M. Moshkin, Gillian E. Chalkley, Karel Bezstarosti#, Jeroen A.A. Demmers#, Christina Rathke, Renate Renkawitz-Pohl, C. Peter Verrijzer (2013) Subunits of the Histone Chaperone CAF1 Also Mediate Assembly of Protamine-Based Chromatin. Cell Reports 4: 1–7.

» Alves RD, Eijken M, Bezstarosti K#, Demmers JA#, van Leeuwen JP (2013)Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix composition and impairing matrix vesicle production. Mol Cell Proteomics 12(10):2890-2900.

» Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J#, Toonen RF, Hoogenraad CC (2013) Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. J Cell Biol 201(6):915-28.

» Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA#, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ (2013) ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. Hum Mol Genet 22(18):3690-704.

» Papageorgiou DN, Demmers J#, Strouboulis J (2013) NP-40 reduces contamination by endogenous biotinylated carboxylases during purification of biotin tagged nuclear proteins. Protein Expr Purif 89(1):80-3.

» Van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J#, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC (2013) TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites. Neuron 77(3):485-502.

» Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, Dos Remedios CG, Carrier L, Demmers JA#, Redwood C, Sadayappan S, van der Velden J (2013) GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine-Rich Region of Cardiac Myosin-Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human. Circ Res 112(4):633-9.

» Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J#, Bezstarosti K#, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N (2012) RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3. Cell 148(4):664-78.

» Schwertman P, Lagarou A, Dekkers DH#, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA#, Fousteri M, Vermeulen W, Marteijn JA (2012) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat Genet 44:598–602.

» Mohd-Sarip A, Lagarou A, Doyen CM, van der Knaap JA, Aslan U, Bezstarosti K#, Yassin Y, Brock HW, Demmers JA#, Verrijzer CP (2012) Transcription-Independent Function of Polycomb Group Protein PSC in Cell Cycle Control. Science 336(6082):744-747.

» Cristina Gontan, Eskeatnaf Mulugeta Achame, Jeroen Demmers, Tahsin Stefan Barakat, Eveline Rentmeester, Wilfred van IJcken, J. Anton Grootegoed & Joost Gribnau (2012) RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. Nature 485(7398):386-90.

» de Graaff E, Maat P, Hulsenboom E, van den Berg R, van den Bent M, Demmers J, Lugtenburg PJ, Hoogenraad CC, Sillevis Smitt P (2012) Identification of delta/notch-like epidermal growth factor-related receptor as the Tr antigen in paraneoplastic cerebellar degeneration. Ann Neurol, doi: 10.1002/ana.23550.

» Brazão TF, Demmers J, van Ijcken W, Strouboulis J, Fornerod M, Romão L, Grosveld FG (2012) A new function of ROD1 in nonsense-mediated mRNA decay. FEBS Lett 24;586(8):1101-1110.

» Karen Sap# & Jeroen AA Demmers# (2012) Labeling Methods in Mass Spectrometry Based Quantitative Proteomics. In H.C. Leung (Ed.) Integrative Proteomics (pp. 111-132). InTech Open Access publishers, ISBN 978-953-51-0070-6.

» McDonel P, Demmers J#, Tan DW, Watt F, Hendrich BD (2012) Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol 363(1):62-73.

» Moshkin YM, Chalkley GE, Kan TW, Reddy BA, Ozgur Z, van Ijcken WF, Dekkers DH#, Demmers JA#, Travers AA, Verrijzer CP (2012) Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific manner. Mol Cell Biol 32(3):675-88.

» Talens S, Lebbink JH, Malfliet JJ, Demmers JA#, Uitte de Willige S, Leebeek FW, Rijken DC (2012) Binding of carboxypeptidase N to fibrinogen and fibrin. Biochem Biophys Res Commun 427(2):421-5.

» Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J#, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A (2012) BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell 23(21):4226-41.

» Jiang K, Toedt G, Montenegro Gouveia S, Davey NE, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen LB, Bezstarosti K#, Lince-Faria M, Demmers J#, Steinmetz MO, Gibson TJ, Akhmanova A (2012) A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. Curr Biol 22(19):1800-7.

» Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J#, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB (2012) Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics 11(11):1263-73.

» Talens S, Leebeek FW, Demmers JA#, Rijken DC (2012) Identification of fibrin clot-bound plasma proteins. PLoS One 7(8):e41966.

» Van Riel B, Pakozdi T, Brouwer R, Monteiro R, Tuladhar K, Franke V, Bryne JC, Jorna R, Rijkers EJ, van Ijcken W, Andrieu-Soler C, Demmers J#, Patient R, Soler E, Lenhard B, Grosveld F (2012) A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. Mol Cell Biol 32(19):3814-22.

» Twigt J, Steegers-Theunissen RP, Bezstarosti K#, Demmers JA# (2012) Proteomic analysis of the microenvironment of developing oocytes. Proteomics 12(9):1463-71.

» Soler E, Andrieu-Soler C, Boer E, Bryne JC, Thongjuea S, Rijkers E#, Demmers J#, Ijcken W, Grosveld F (2011) A systems approach to analyze transcription factors in mammalian cells. Methods 53(2):151-62.

» Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, Appanah R, Bezstarosti K#, Demmers J#, Koseki H, Brockdorff N. Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development [Epub ahead of print]

» Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH#, Demmers J#, Rijkers EJ#, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA (2011) Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet 43(6):607-11.

» Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J#, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A (2011) Rab6, Rab8, and MICAL3 Cooperate in Controlling Docking and Fusion of Exocytotic Carriers. Curr Biol 21(11):967-74.

» Esteghamat F, van Dijk TB, Braun H, Dekker S, van der Linden R, Hou J, Fanis P, Demmers J#, van Ijcken W, Ozgur Z, Horos R, Pourfarzad F, von Lindern M, Philipsen S (2011) The DNA binding factor Hmg20b is a repressor of erythroid differentiation. Haematologica [Epub ahead of print]

» Meenhuis A, van Veelen PA, de Looper H, van Boxtel N, van den Berge IJ, Sun SM, Taskesen E, Stern P, de Ru AH, van Adrichem AJ, Demmers J#, Jongen-Lavrencic M, Löwenberg B, Touw IP, Sharp PA, Erkeland SJ (2011) MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice. Blood [Epub ahead of print]

» Kapitein LC, Yau KW, Gouveia SM, van der Zwan WA, Wulf PS, Keijzer N, Demmers J#, Jaworski J, Akhmanova A, Hoogenraad CC (2011) NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry. J Neurosci 31(22):8194-209.

» Van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J#, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A (2011) SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J Cell Biol 193(6):1083-99.

» Cui S, Kolodziej K, Obara N, Amaral-Psarris A, Demmers J#, Shi L, Engel JD, Grosveld F, Strouboulis J, Tanabe O (2011) Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Co-repressors that Associate Specifically with the Embryonic {beta}-type Globin Promoters in Differentiated Adult Erythroid Cells. Mol Cell Biol [Epub ahead of print]

» Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA#, Strouboulis J, Baud V (2011) A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem 286(37):32277-88.

» Alves RD, Demmers JA#, Bezstarosti K#, van der Eerden BC, Verhaar JA, Eijken M, van Leeuwen JP (2011) Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library. J Proteome Res 10(10):4725-33.

» Domingues I, Rino J, Demmers JA#, de Lanerolle P, Santos SC (2011) VEGFR2 translocates to the nucleus to regulate its own transcription. PLoS One 6(9):e25668.

» Karel Bezstarosti*#, Alireza Ghamari*, Frank G. Grosveld, Jeroen A. A. Demmers#. Differential proteomics based on 18O labeling to determine the Cyclin Dependent Kinase 9 interactome. J Proteome Res 9(9):4464-75.

» Reddy BA, Bajpe PK, Bassett A, Moshkin YM, Kozhevnikova E, Bezstarosti K#, Demmers JA#, Travers AA, Verrijzer CP. Drosophila Transcription Factor Tramtrack69 Binds MEP1 to Recruit the Chromatin Remodeler NuRD. Mol Cell Biol 30(21):5234-44.

» David Landeira, Stephan Sauer, Raymond Poot, Maria Dvorkina, Luca Mazzarella, Helle F. Jørgensen, C. Filipe Pereira, Marion Leleu, Francesco M. Piccolo, Mikhail Spivakov, Emily Brookes, Ana Pombo, Cynthia Fisher, William C. Skarnes, Tim Snoek, Karel Bezstarosti#, Jeroen Demmers#, Robert J. Klose, Miguel Casanova, Ligia Tavares, Neil Brockdorff, Matthias Merkenschlager & Amanda G. Fisher. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol 12(6):618-24.

» Arnaud Krebs, Jeroen Demmers#, Krishanpal Karmodiya, Nan-Chi Chang, Alice Chien Chang, László Tora. ATAC and Mediator coactivators form a stable complex to regulate a set of non-coding RNA genes. EMBO Rep 11(7):541-7.

» van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K#, Demmers J#, Chambers I, Poot RA. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6(4):369-81.

» Daniël Splinter, Marvin E. Tanenbaum, Arne Lindqvist, Dick Jaarsma, Annette Flotho, Ka Lou Yu, Ilya Grigoriev, Dieuwke Engelsma, Elize D. Haasdijk, Nanda Keijzer, Jeroen Demmers#, Maarten Fornerod, Frauke Melchior, Casper C. Hoogenraad, René H. Medema & Anna Akhmanova. Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulte Centrosome and Nuclear Positioning during Mitotic Entry. PLoS Biology 8(4): e1000350.

» van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J#, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol 30(1):260-72.

» Van de Nobelen S, Rosa-Garrido M, Leers J, Heath H, Soochit W, Joosen L, Jonkers I, Demmers J#, van der Reijden M, Torrano V, Grosveld F, Delgado MD, Renkawitz R, Galjart N, Sleutels F. CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin 3(1):19.

» Kubben N, Voncken JW, Demmers J#, Calis C, van Almen G, Pinto Y, Misteli T. Identification of differential protein interactors of lamin A and progerin. Nucleus 1(6):513-525.

» J. Jaworski, L.C. Kapitein, S.M. Gouveia, B.R. Dortland, P.S. Wulf, I. Grigoriev, P. Camera, S.A. Spangler, P. Di Stefano, J. Demmers#, H. Krugers, P. Defilippi, A. Akhmanova, and C.C. Hoogenraad (2009) Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity. Neuron 61: 85-100.

» Gontan C, Güttler T, Engelen E, Demmers J#, Fornerod M, Grosveld FG, Tibboel D, Görlich D, Poot RA, Rottier RJ. (2009) Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. J Cell Biol 185: 27-34.

» Niessen, HEC, Demmers, JAA# & Voncken, JW (2009) Talking to chromatin: post-translational modulation of polycomb group function. Epigenetics & Chromatin 2:10.

» Yuri M Moshkin, Tsung Wai Kan, Henry Goodfellow, Karel Bezstarosti#, Robert K Maeda, Maxim Pilyugin, Francois Karch, Sarah Bray, Jeroen A. A Demmers# & Peter Verrijzer (2009) Histone Chaperone ASF1 Cooperates with a LID/KDM5 Histone H3K4me2/3 Demethylase Complex to Mediate Gene-Selective Silencing. Mol Cell 35(6):782-93.

» Maxim Pilyugin, Jeroen Demmers#, Peter C. Verrijzer, Francois Karch, and Yuri M. Moshkin (2009) Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. PLoS ONE 4(12):e8328.

» Wong HY, Demmers JA#, Bezstarosti K#, Grootegoed JA, Brinkmann AO (2009) DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor. Biochim Biophys Acta 1794(2):193-8.

» B. R. Prashanth Kumar, Jan A. van der Knaap, Jeroen A. A. Demmers#, Karel Bezstarosti#, Helen van Beusekom, Andrew A. Travers and C. Peter Verrijzer (2008) Ubiquitin Protease 64 Controls Cell Fate Through Stabilization of the Transcriptional Repressor Tramtrack. Mol Cell Biol 28: 1606-15.

» Dekkers DH#, Bezstarosti K#, Gurusamy N, Luijk K, Verhoeven AJ, Rijkers EJ#, Demmers JA#, Lamers JM, Maulik N, Das DK (2008) Identification by a differential proteomic approach of the induced stress and redox proteins by resveratrol in the normal and diabetic rat hearts. J Cell Mol Med 12(5A):1677-89.

» Ilya Grigoriev, Susana Montenegro Gouveia, Babet van der Vaart, Jeroen Demmers#, Jeremy T. Smyth, Srinivas Honnappa, Daniël Splinter, Michel O. Steinmetz, James W. Putney, Jr, Casper C. Hoogenraad and Anna Akhmanova (2008) STIM1 is a microtubule plus end tracking protein involved in remodeling of the endoplasmic reticulum. Curr Biol 18: 177-82.

» Gillian E. Chalkley, Yuri M. Moshkin, Karin Langenberg, Karel Bezstarosti#, Andras Blastyak, Henrik Gyurkovics, Jeroen A. A. Demmers#, and C. Peter Verrijzer (2008) The Transcriptional Co-activator SAYP is a Trithorax Group Signature Subunit of the PBAP Chromatin Remodeling Complex. Mol Cell Biol 28: 2920-9.

» Debbie L. C. van den Berg, Wensheng Zhang, Adam Yates, Erik Engelen, Katalin Takacs, Karel Bezstarosti#, Jeroen Demmers#, Ian Chambers, Raymond A. Poot (2008) The Estrogen Related Receptor Beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol 28: 5986-95.

» Anna Lagarou, Adone Mohd-Sarip, Yuri M. Moshkin, Gillian E. Chalkley, Karel Bezstarosti#, Jeroen A. A. Demmers#, and C. Peter Verrijzer (2008) dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev 22: 2799-810.

» Carmen Sánchez, Inés Sánchez, Jeroen A. A. Demmers# , Patrick Rodriguez, John Strouboulis & Miguel Vidal (2007) Proteomic analysis of RING1B / RNF2 interactors identifies a novel complex with the FBXL10 / JMJD1B histone demethylase and the BCOR corepressor. Mol Cell Proteomics 6: 820-34.

» Ilya Grigoriev, Daniël Splinter, Nanda Keijzer, Phebe S. Wulf, Jeroen Demmers# , Toshihisa Ohtsuka, Mauro Modesti, Ivan V. Maly, Frank Grosveld, Casper C. Hoogenraad and Anna Akhmanova (2007) Rab6 regulates transport and targeting of exocytotic carriers. Dev Cell 13: 305-14.

» Eva Teuling, Suaad Ahmed, Elize Haasdijk, Jeroen Demmers#, Michel O Steinmetz, Anna Akhmanova, Dick Jaarsma and Casper Hoogenraad (2007) Motor neuron disease-associated mutant VAPB recruits wild type VAPs into tubular aggregates and perturbs FFAT binding. J Neurosci 27: 9801-01.

» Mauro Modesti, Magda Budzowska, Céline Baldeyron, Jeroen Demmers#, Rodolfo Ghirlando and Roland Kanaar (2007) RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol Cell 28: 468-481.

» Mari PO, Florea BI, Persengiev SP, Verkaik NS, Brüggenwirth HT, Modesti M, Giglia-Mari G, Bezstarosti K#, Demmers JA#, Luider TM, Houtsmuller AB, van Gent DC (2006) Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A 103(49):18597-602.

» Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J#, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (2006) CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. Dev Cell 11(1):21-32.

» van den Bemd GJ, Krijgsveld J, Luider TM, van Rijswijk AL, Demmers JA#, Jenster G (2006) Mass spectrometric identification of human prostate cancer-derived proteins in serum of xenograft-bearing mice. Mol Cell Proteomics 5(10):1830-9.

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