Proteins play important roles in cells and tissues. Some proteins provide structural integrity, others catalyze reactions and yet others regulate gene expression. Proteomics is the large-scale experimental analysis of the functions and interactions of all the proteins in a cell or organism (i.e., the proteome), which can number in the thousands or millions of variations. Proteomics often refers specifically to protein purification and mass spectrometry.
The Proteomics Center at Erasmus MC offers state-of-the-art mass spectrometry (MS) based methodologies for qualitative and quantitative proteomics analysis, including data independent acquisition (DIA) MS, targeted proteomics (PRM), multiplexed isobaric labeling, etc.
The Proteomics Center team is composed of scientists and technicians with backgrounds in analytical chemistry, biochemistry, cell biology, liquid chromatography, mass spectrometry and (bio)informatics. This concentrated knowledge makes it possible to tailor an analysis to very diverse and specific questions. The Center is embedded in the Erasmus MC scientific research core facilities infrastructure and provides services for the Erasmus MC scientific community and also for researchers from other academic institutions and industry. Research projects in our laboratory focus on the analysis of protein post-translational modifications (PTMs), the elucidation of protein-protein interactions and complex composition, the analysis of proteome dynamics in cell cultures and tissue and proteomics and mass spectrometry methodology development.
The ultimate goal of our research is to develop analytical tools to better understand how cellular processes are controlled at the molecular level in health and disease.
Director: Dr. Jeroen Demmers
Our lab is part of the NWO National Roadmap for Large-scale Research Infrastructures.
👉 We are always looking for smart and motivated students. Positions for MSc or BSc students in analytical chemistry or biochemistry are available on a regular basis – see project descriptions. If you are interested, please send us your CV and a motivation letter.