Understanding proteome complexity

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Proteins play important roles in cells and tissues. Some proteins provide structural integrity, others catalyze reactions, and yet others regulate gene expression. Proteomics is the study of the structure, function, and interaction of all the proteins in a cell or organism, which can number in the hundreds of thousands or millions of variations.

The Proteomics Center at Erasmus MC develops mass spectrometry based methodologies for qualitative and quantitative (SILAC, TMT, etc.) proteomics analysis. The Center provides services for the Erasmus MC scientific community and external researchers. Research projects in our laboratory focus on the analysis of protein post-translational modifications, the elucidation of protein-protein interactions and complex composition and the analysis of proteome dynamics, both in cell cultures and tissue. The ultimate goal of our research is to develop analytical tools to better understand how cellular processes are controlled at the molecular level in health and disease.

Director: Dr. Jeroen Demmers

Our lab is part of the NWO National Roadmap for Large-scale Research Infrastructures:

 

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Our paper on the characterization of novel molecular targets of the ubiquitin-specific protease 7 (USP7) is out now in Science Advances! We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network, which helps in understanding the role of USP7 in cancer progression and neurodevelopment. Great and fruitful multi-omics collaboration with the Verrijzer Lab at Erasmus MC 💪

 

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The Journal of Visualized Experiments has published a video article on the sample preparation and analysis of diGly peptides from ubiquitinated proteins featuring our lab. Watch the full video here.

 

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Finally out! Paper on the detection of SARS-CoV-2 proteins by targeted proteomics in PLOS ONE. There is still a version of the manuscript on bioRxiv as well.

 

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We are always looking for smart and motivated students. Positions for MSc or BSc students in analytical chemistry or biochemistry are available on a regular basis – see project descriptions. If you are interested, please send us your CV and a motivation letter.

 

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