Proteins play important roles in cells and tissues. Some proteins provide structural integrity, others catalyze reactions, and yet others regulate gene expression. Proteomics is the study of the structure, function, and interaction of all the proteins in a cell or organism, which can number in the hundreds of thousands or millions of variations.
The Proteomics Center at Erasmus MC develops mass spectrometry based methodologies for qualitative and quantitative (SILAC, TMT, etc.) proteomics analysis. The Center provides services for the Erasmus MC scientific community and external researchers. Research projects in our laboratory focus on the analysis of protein post-translational modifications, the elucidation of protein-protein interactions and complex composition and the analysis of proteome dynamics, both in cell cultures and tissue. The ultimate goal of our research is to develop analytical tools to better understand how cellular processes are controlled at the molecular level in health and disease.
Director: Dr. Jeroen Demmers
Our lab is part of the NWO National Roadmap for Large-scale Research Infrastructures:
Our paper on the characterization of novel molecular targets of the ubiquitin-specific protease 7 (USP7) is out now in Science Advances! We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network, which helps in understanding the role of USP7 in cancer progression and neurodevelopment. Great and fruitful multi-omics collaboration with the Verrijzer Lab at Erasmus MC 💪