Jeroen Demmers

Dr. Jeroen Demmers

Director Proteomics Core Facility | Assistant Professor

EUR Fellow, Erasmus University Medical Center

Postdoc, The Rockefeller University, New York (Chait lab)

PhD, Utrecht University (Heck & Killian labs)

MSc (hons) Chemistry, Utrecht University

Research interests

mass spectrometry based proteomics
quantitation in proteomics (SILAC, TMT, etc.)
targeted proteomics
protein complex and protein-protein interaction networks
characterization of posttranslational protein modifications
the ubiquitin-proteasome system
transcription and gene regulation in health and disease
chromatin biology

Selected publications

van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA (2010) An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6(4):369-81. (Oct4 | interaction network)
Sap KA#, Bezstarosti K#, Dekkers DH#, van den Hout M, van Ijcken W, Rijkers E#, Demmers JAA (2015) Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster. Proteomics 15(4):725-38.
Karel Bezstarosti*, Alireza Ghamari*, Frank G. Grosveld, Jeroen A. A. Demmers (2010) Differential proteomics based on ¹⁸O labeling to determine the Cyclin Dependent Kinase 9 interactome. J Proteome Res 9(9):4464-75. (quantitation | ¹⁸O labeling | protein complex elucidation)
Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL (2013) Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495(7440):251-4.
Adone Mohd-Sarip, Anna Lagarou, Ulku Aslan, Jan van der Knaap, Cecile Doyen, Karel Bezstarosti, Yasmin Yassin, Hugh W Brock, Jeroen AA Demmers & C. Peter Verrijzer (2012) Transcription-independent function of the Polycomb group protein PSC in cell cycle control. Science 336(6082):744-7. (PSC | protein complex elucidation)
Yu N, Signorile L, Basu S, Ottema S, Lebbink JH, Leslie K, Smal I, Dekkers D#, Demmers J#, Galjart N (2016) Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells. Curr Biol 26(13):1728-36.
Schwertman, P., Lagarou, A., Dekkers, D. H. W., Raams, A., van der Hoek, A. C., Laffeber, C., Hoeijmakers, J. H. J., Demmers, J. A. A., Fousteri, M., Vermeulen, W. & Marteijn, J. A. (2012) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nature Genetics 44(5):598-602. (quantitation | SILAC | ubiquitinome)

Teaching

Faculty member BSc Nanobiology (TU Delft / Erasmus MC) – courses Chemistry I NB1102 & Chemistry II NB1110 (6 ECTS)
Faculty member MSc Nanobiology (TU Delft / Erasmus MC) – course Engineering Genetic Information NB4030 – proteomics (3 ECTS)
Instructor and organizer of the MolMed PhD course ‘Biomolecular Research Techniques: Proteomics’
Instructor and organizer of the MGC PhD course ‘Technology Facilities: Proteomics’
Faculty member of the MSc Molecular Medicine research school