» March 2013 | Collaborative research paper on a novel human receptor for emerging coronavirus published in Nature - cover story! :-)
Human receptor for emerging coronavirus The emerging pathogenic coronavirus hCoV-EMC, first identified in September 2012, has been fatal in about half of the few humans infected so far. We have now identified the receptor that this virus uses to infect cells. In contrast to the related virus SARS-CoV, which uses angiotensin converting enzyme 2, the functional receptor for hCoV-EMC is dipeptidyl peptidase 4 (DPP4, also known as CD26), an exopeptidase found on non-ciliated cells in the lower respiratory tract. This enzyme is highly conserved across different species, and hCoV-EMC can also use bat DPP4 as a functional receptor — a possible clue as to the host range and epidemiological history of this new virus. The findings may also be important for the development of intervention strategies.
» Citation: V. Stalin Raj et al. (2013) Nature | Vol 495 | Number 7440 | 14 March 2013 | pp 251-254
» See also: Nature News item and New & Views by Gallaghar & Perlman
» For the general public: article in Dutch national newspaper NRC (in Dutch!)
» April 2012 | Four collaborative research papers published in Nature, Cell, Science and Nature Genetics!
Þ Cristina Gontan, Eskeatnaf Mulugeta Achame, Jeroen Demmers#, Tahsin Stefan Barakat, Eveline Rentmeester, Wilfred van IJcken, J. Anton Grootegoed and Joost Gribnau (2012) RNF12 initiates X chromosome inactivation by targeting REX1 for degradation. Nature, doi:10.1038/nature11070.
Þ Schwertman, P., Lagarou, A., Dekkers, D. H. W.#, Raams, A., van der Hoek, A. C., Laffeber, C., Hoeijmakers, J. H. J., Demmers, J. A. A.#, Fousteri, M., Vermeulen, W. & Marteijn, J. A. (2012) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nature Genetics, doi:10.1038/ng.2230.
Þ Adone Mohd-Sarip, Anna Lagarou, Ulku Aslan, Jan van der Knaap, Cecile Doyen, Karel Bezstarosti#, Yasmin Yassin, Hugh W Brock, Jeroen AA Demmers# & C. Peter Verrijzer (2012) Transcription-independent function of the Polycomb group protein PSC in cell cycle control. Science, doi:10.1126/science.1215927.
Þ Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J#, Bezstarosti K#, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N (2012) RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 148(4):664-78.
» March 2012 | 13.5 M€ NWO investment for large-scale proteomics research facility 'Proteins@Work' granted to a consortium of universities and research institutes, including Erasmus MC Rotterdam.
» January 2012 | Book chapter on labeling methods in mass spectrometry based quantitative proteomics published in 'Integrative Proteomics' (InTech Open Access publisher, ISBN 978-953-51-0070-6).
» November 2011 | New Q Exactive (Thermo) installed in the lab!
» October 2011 | 'Walk in' consultation hours in Ee-675: Friday 3-5 PM ONLY.
» September 2010 | FAQs added to the website.
» July 2010 | New paper in J Proteome Res on 18O labeling for differential proteomics, applied to identification of the Cdk9 interactome.
» June 2010 | New Waters Xevo Q-ToF and Xevo TQ mass spectrometers up and running (see Equipment).
» January 2010 | New lab member Karen Sap starts her PhD research project.
» January 2009 | Netherlands Proteomics Center investment grant to set up a 'National Research Hotel' infrastructure.
» October 2008 | Horizon Breakthrough grant awarded to Jeroen Demmers for a project entitled 'Hormone signaling pathways investigated by quantitative proteomic methods' by the Netherlands Genomics Initiative.
» July 2008 | Erasmus MC grant (Mrace pilot project) awarded to Jeroen Demmers and Régine Steegers-Theunissen for a collaborative project entitled 'Proteomic analysis of human follicular fluid to assess oocyte quality'.
» May 2008 | 1.1 M€ 'NWO-Groot' grant awarded for (amongst others) a high-resolution mass spectrometer with electron transfer dissociation capabilities. See website of the Dutch Organization for Scientific Research (NWO) for more information.