The Proteomics Center at Erasmus MC develops mass spectrometry based proteomics methodologies for the qualitative and quantitative analysis of (sub)proteomes and provides proteomics services for the Erasmus MC scientific community and for external researchers. The research projects in our laboratory focus on the elucidation of protein complex composition, the analysis of protein posttranslational modifications ('functional proteomics') and on the analysis of (sub)cellular proteomes and the dynamics thereof. For this, we use high sensitivity and high accuracy, quantitative mass spectrometry (nanoLC-MS/MS) combined with SILAC, dimethylation, 18O or isobaric (iTRAQ/TMT) labeling. The ultimate goal of our research is to develop analytical tools to better understand how cellular processes are controlled at the molecular level.
|The Proteomics Center is supported by:|